Biodiversity Research Center, Academia Sinica

Dr. Yin-Ru Chiang Associate Research Fellow

Lab PI

Dr. Yin-Ru Chiang

Associate Research Fellow

PhD – University of Freiburg, Germany, 2007

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Office: Interdisciplinary Research Building for Science and Technology B305


Research Fields
  • Microbial metabolic diversity
  • Microbial ecophysiolog
  • Biodegradation and bioremediation

Research Directions

  • 1.Microbial degradation of steroids
    Steroids are ubiquitous and abundant in nature. Microbial steroid degradation is relevant to elemental cycles. In addition, these compounds play important roles in the physiology and development of animals as well as microbe-host interactions. For instance, Mycobacterium tuberculosis relies on host cholesterol for its survival. In previous studies, we have identified biochemical mechanisms and enzymes involved in anaerobic biodegradation of cholesterol and testosterone. These anaerobic pathways involve numerous unprecedented biochemical reactions. Currently, we are studying aerobic and anaerobic estrogen biodegradation. Natural and synthetic estrogens are discharged into environments through human activities, livestock, and pharmaceutical industry. Exposure to estrogens (sub-ng/L) may cause adverse effects on the reproductive systems of wildlife and human. Using bacterial strains isolated from wastewater treatment plants as model organisms, we attempt to investigate biochemical mechanisms involved in microbial estrogen degradation. The catabolic genes and signature metabolites may be used as biomarkers for environmental survey. Our studies of steroid biodegradation have significance and potential applications in microbiology, biogeochemistry, bioremediation, and pharmaceutical biotechnology.
  • 2.Physiological adaptation mechanisms of themoacidiophilic red algae under extreme environmental conditions
    Thermoacidiophilic red algae (Cyanidiophycaea) are unique eukaryotic microbes that grow at high temperatures (up to 55°C) in acidic hot springs. These extremophilic unicellular algae display an extraordinary metabolic versatility and can grow photoautotrophically, chemoheterotrophically, or mixotrophically. Red algae can produce abundant carotenoids and phycocyanin with antioxidative properties, and offer great potential for biotechnology industries. Thermoacidiophilic red algae show remarkable adaptability for alternative energy sources, yet our knowledge of the physiological adaptation mechanisms to light intensities and exogenous carbon sources is limited. Using multi-omics approaches to determine the photosynthetic apparatus characters and lipidomic profiles of red algae under different cultivation conditions, we attempt to identify the biomarkers for differentiating photoautotrophic, heterotrophic, and mixotrophic states, which may serve as an important criterion for identifying physiological traits of red algae in the environment.


Latest published paper

期刊論文 ( 2016 - 2019 )

  1. Mei-Chuan Chen, Guei-Jane Wang, Yueh-Hsiung Kuo, Yin-Ru Chiang, Ting-Yu Cho, Yu-Ming Ju, Tzong-Huei Lee*, accepted, “Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata”, JOURNAL OF FOOD AND DRUG ANALYSIS. (SCI) (IF: 3.048; SCI ranking: 32.7%,17.7%) Link
  2. Kan Wu, Tzong-Huei Lee, Yi-Lung Chen, Yu-Sheng Wang, Po-Hsiang Wang, Chang-Ping Yu, Kung-Hui Chu, and Yin-Ru Chiang*, 2018, “Identification of metabolites involved in the aerobic degradation of estrogen A/B-rings”, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 85, e02223-18. (SCI) (IF: 3.807; SCI ranking: 20.6%,23.2%) Link
  3. Sean Ting-Shyang Wei, Yu-Wei Wu, Tzong-Huei Lee, Yi-Shiang Huang, Cheng-Yu Yang, Yi-Lung Chen, and Yin-Ru Chiang*, 2018, “Microbial functional responses to cholesterol catabolism in denitrifying sludge”, mSystems, 3(5), e00113-18. (SCI) Link
  4. Min Lv, Ching Lo, Cheng-Chih Hsu, Yuwen Wang, Yin-Ru Chiang, Qian Sun, Yang Wu, Yan Li, Lingxin Chen, Chang-Ping Yu*, 2018, “Identification of enantiomeric byproducts during microalgae-mediated transformation of metoprolol by MS/MS spectrum-based networking”, FRONTIERS IN MICROBIOLOGY, 9, 2115. (SCI) (IF: 4.076; SCI ranking: 20.8%) Link
  5. Yi-Lung Chen, Han-Yi Fu, Tzong-Huei Lee, Chao-Jen Shih, Lina Huang, Yu-Sheng Wang, Wael Ismail, and Yin-Ru Chiang*, 2018, “Identification of estrogen degradation pathway and estrogen degraders in an activated sludge”, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 84, 84:e00001-18. (SCI) (IF: 3.807; SCI ranking: 20.6%,23.2%) Link
  6. Hisayoshi Nozaki1*, Noriko Ueki, Mari Takusagawa, Shota Yamashita, Osami Misumi, Ryo Matsuzaki, Masanobu Kawachi, Yin-Ru Chiang, and Jiunn-Tzong Wu, 2018, “Morphology, taxonomy and mating-type loci in natural populations of Volvox carteri in Taiwan”, BOTANICAL STUDIES, 59(1), 10. (SCI) (IF: 1.452; SCI ranking: 44.8%) Link
  7. Chao-Jen Shih, Yi-Lung Chen, Chia-Hsiang Wang, Sean Ting-Shyang Wei, I-Ting Lin, Wael Ahmed Ismail, and *Yin-Ru Chiang, 2017, “Biochemical mechanisms and microorganisms involved in anaerobic androgen metabolism in estuarine sediments.”, FRONTIERS IN MICROBIOLOGY, 8, 1520. (SCI) (IF: 4.076; SCI ranking: 20.8%) Link
  8. Yi-Lung Chen, Chang-Ping Yu, Tzong-Huei Lee, King-Siang Goh, Kung-Hui Chu, Po-Hsiang Wang, Wael Ismail, Chao-Jen Shih, and Yin-Ru Chiang*, 2017, “Biochemical Mechanisms and Catabolic Enzymes Involved in Bacterial Estrogen Degradation Pathways”, CHEMISTRY & BIOLOGY, 24, 712-724. (SCI) (IF: 6.743; SCI ranking: 11%) Link
  9. Yi-Lung Chen, Chia-Hsiang Wang, Fu-Chun Yang, Wael Ismail, Po-Hsiang Wang, Chao-Jen Shih, Yu-Ching Wu, and Yin-Ru Chiang*, 2016, “Identification of Comamonas testosteroni as an androgen degrader in sewage.”, Scientific Reports, 6, 35386. (SCI) (IF: 4.259; SCI ranking: 15.6%) Link
  10. Fu-Chun Yang, Yi-Lung Chen, Sen-Lin Tang, Chang-Ping Yu, Po-Hsiang Wang, Wael Ismail, Chia-Hsiang Wang, Jiun-Yan Ding, Cheng-Yu Yang, Chia-Ying Yang, and Yin-Ru Chiang*, 2016, “Integrated multi-omics analyses reveal the biochemical mechanisms and phylogenetic relevance of anaerobic androgen biodegradation in the environment”, ISME Journal, 10, 1967-1983. (SCI) (IF: 9.664; SCI ranking: 2%,5.6%) Link
  11. Jiun-Yan Ding,Jia-Ho Shiu,Wen-Ming Chen, Yin-Ru Chiang, and Sen-Lin Tang, 2016, “Genomic insight into the host-endosymbiont relationship of Endozoicomonas montiporae CL-33 with its coral host.”, Frontiers in Microbiology, 7, 251. (SCI) (IF: 4.076; SCI ranking: 20.8%) Link
專書(論文集)之一章 ( 2016 - 2019 )
  1. *Yin-Ru Chiang and Wael Ismail, 2017, “Chapter title: Anaerobic biodegradation of steroids”, editor(s): Timmis, Kenneth N, Volume 5: Anaerobic Utilization of Hydrocarbons, Oils and Lipids (Boll, Matthias, ed.), Handbook of Hydrocarbon and Lipid Microbiology Series, pp. 1-32, Berlin Heidelberg, Germany: Springer-Verlag.

Lab members


電  話

傅翰儀     陳宜龍     魏廷翔

高麗珠     黃翊翔     王郁盛

李芊穎     李語珊     張雅鈞