Biodiversity Research Center, Academia Sinica

Dr. Yin-Ru Chiang Acting Deputy Director/ Associate Research Fellow

Lab PI

Dr. Yin-Ru Chiang

Acting Deputy Director/ Associate Research Fellow

PhD – University of Freiburg, Germany, 2007

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Office: Interdisciplinary Research Building for Science and Technology B305


Research Fields
  • Microbial metabolic diversity
  • Biodegradation and bioremediation
  • Microbial ecophysiolog
  • Meta-omics analysis

Research Directions

  • 1.The pivotal roles of B12 analogs in anaerobic microbial interactions
     Vitamin B12 and its analogs (namely cobamides) are the most complicated organometallic cofactors used in biology to catalyze essential biochemical reactions including the biosynthesis of amino acids, DNA, and fatty acids. Moreover, Vitamin B12-mediated reactions are pivotal in biogeochemical cycles of carbon, halogen, and heavy metals. Cobamides are required by organisms within all three domains of life, but are produced by only a subset of bacteria and archaea. Thus, the procurement of the vitamin from the few prokaryotic producers plays an essential function in microbial interspecies interactions. Cobamides reveal an outstanding structural-diversity in anaerobic biosphere; thus far, more than 17 different cobamides have been isolated and characterized from anaerobic prokaryotes. However, their exacting roles in anaerobic microbial metabolism remain to be further elucidated. Also, the key producers of cobamides in each anaerobic ecosystems remain to be identified. Recently, we demonstrated that cobamides are pivotal in anaerobic steroid metabolism. We aim to answer the following questions: (i) how cobamides are synthesized, transferred, and the interplay between anaerobes, (ii) how cobamides help to shape the anaerobic microbial communities, (iii) what are the roles of cobamides in anaerobic bioprocesses such as biodegradation of endocrine disruptors, and (iv) why so many different cobamides are produced in anaerobic biosphere?
  • 2.Biodegradation and bioremediation of major endocrine disruptors
     The widespread occurrence and persistence of endocrine disruptors, including estrogens and phthalate esters (PAEs), have attracted public attention due to their endocrine-disrupting effects on both wildlife and human beings. Because of the global urbanization, these major endocrine disruptors can be detected almost everywhere in our environments, including deep ocean and polar region. Microbial degradation has been considered as the major mechanism for removing these endocrine disruptors from the biosphere. Aerobic biodegradation of these compounds relies on O2 as a co-substrate of oxygenases; by contrast, little is known about the biochemical mechanisms and catabolic genes involved in the anaerobic biodegradation. By using bacterial isolates or consortia as model organisms, we attempt to investigate biochemical mechanisms involved in anaerobic degradation of estrogens and PAEs. The catabolic genes and signature metabolites may be used as biomarkers for environmental survey. We also apply meta-omics approaches to identify the essential cofactors (e.g., corrinoids) and key degraders in the polluted ecosystems. Our studies have significance and potential applications in microbiology, biogeochemistry, bioremediation, and environmental biotechnology.


Latest published paper

期刊論文 ( 2015 - 2020 )

  1. Chun-Wei Chang, Hao Ye, Takeshi Miki, Ethan R Deyle, Souissi Sami, Orlane Anneville, Rita Adrian, Yin-Ru Chiang, Satoshi Ichise, Michio Kumagai, Shin-Ichiro S Matsuzaki, Fuh-Kwo Shiah, Jiunn-Tzong Wu, Chih-Hao Hsieh, George Sugihara, 2020, “Long-term warming destabilizes aquatic ecosystems through weakening biodiversity-mediated causal networks”, GLOBAL CHANGE BIOLOGY, doi: 10.1111/gcb.15323.
  2. Jih-Jung Chen, Shih-Wei Wang, Yin-Ru Chiang, Ka-Lai Pang, Yueh-Hsiung Kuo, Tsai-Yen Shih, and Tzong-Huei Lee, 2020, “Highly oxygenated constituents from a marine alga-derived fungus Aspergillus giganteus NTU967”, MARINE DRUGS, 18(6):303.
  3. Han-Yi Fu, Shao-Lun Liu, Yin-Ru Chiang*, 2020, “Biosynthesis of ascorbic acid as a glucose-induced photoprotective process in the extremophilic red alga Galdieria partita.”, Frontiers in Microbiology, 10, 3005. (SCIE) (IF: 4.019; SCIE ranking: 25.4%) Link
  4. Po-Hsiang Wang, Yi-Lung Chen, Sean Ting-Shyang Wei, Kan Wu, Tzong-Huei Lee, Tien-Yu Wu, and Yin-Ru Chiang*, 2020, “Retroconversion of estrogens into androgens by bacteria via a cobalamin-mediated methylation”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(3), 1395-1403. (SCIE) (IF: 9.504; SCIE ranking: 7.8%) Link
  5. Yin-Ru Chiang*, Sean Ting-Shyang Wei, Po-Hsiang Wang, Pei-Hsun Wu, Chang-Ping Yu, 2019, “Microbial degradation of steroid sex hormones: Implications for environmental and ecological studies.”, MICROBIAL BIOTECHNOLOGY, DOI: 10.1111/1751-7915.13504. (SCIE) (IF: 3.913; SCIE ranking: 20.5%,27%) Link
  6. Kan Wu, Tzong-Huei Lee, Yi-Lung Chen, Yu-Sheng Wang, Po-Hsiang Wang, Chang-Ping Yu, Kung-Hui Chu, and Yin-Ru Chiang*, 2019, “Metabolites Involved in Aerobic Degradation of the A and B Rings of Estrogen”, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 85(3), e02223-18. (SCIE) (IF: 3.807; SCIE ranking: 20.6%,23.2%) Link
  7. Mei-Chuan Chen, Guei-Jane Wang, Yueh-Hsiung Kuo, Yin-Ru Chiang, Ting-Yu Cho, Yu-Ming Ju, Tzong-Huei Lee*, 2019, “Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata”, JOURNAL OF FOOD AND DRUG ANALYSIS, 27(1),111-117. (SCIE) (IF: 3.048; SCIE ranking: 32.7%,17.7%) Link
  8. Sean Ting-Shyang Wei, Yu-Wei Wu, Tzong-Huei Lee, Yi-Shiang Huang, Cheng-Yu Yang, Yi-Lung Chen, and Yin-Ru Chiang*, 2018, “Microbial functional responses to cholesterol catabolism in denitrifying sludge”, mSystems, 3(5), e00113-18. (SCIE) (IF: 5.75; SCIE ranking: 13.5%) Link
  9. Min Lv, Ching Lo, Cheng-Chih Hsu, Yuwen Wang, Yin-Ru Chiang, Qian Sun, Yang Wu, Yan Li, Lingxin Chen, Chang-Ping Yu*, 2018, “Identification of enantiomeric byproducts during microalgae-mediated transformation of metoprolol by MS/MS spectrum-based networking”, FRONTIERS IN MICROBIOLOGY, 9, 2115. (SCIE) (IF: 4.076; SCIE ranking: 20.8%) Link
  10. Yi-Lung Chen, Han-Yi Fu, Tzong-Huei Lee, Chao-Jen Shih, Lina Huang, Yu-Sheng Wang, Wael Ismail, and Yin-Ru Chiang*, 2018, “Identification of estrogen degradation pathway and estrogen degraders in an activated sludge”, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 84, 84:e00001-18. (SCIE) (IF: 3.807; SCIE ranking: 20.6%,23.2%) Link
  11. Hisayoshi Nozaki1*, Noriko Ueki, Mari Takusagawa, Shota Yamashita, Osami Misumi, Ryo Matsuzaki, Masanobu Kawachi, Yin-Ru Chiang, and Jiunn-Tzong Wu, 2018, “Morphology, taxonomy and mating-type loci in natural populations of Volvox carteri in Taiwan”, BOTANICAL STUDIES, 59(1), 10. (SCIE) (IF: 1.452; SCIE ranking: 44.8%) Link
  12. Chao-Jen Shih, Yi-Lung Chen, Chia-Hsiang Wang, Sean Ting-Shyang Wei, I-Ting Lin, Wael Ahmed Ismail, and Yin-Ru Chiang*, 2017, “Biochemical mechanisms and microorganisms involved in anaerobic androgen metabolism in estuarine sediments.”, FRONTIERS IN MICROBIOLOGY, 8, 1520. (SCIE) (IF: 4.076; SCIE ranking: 20.8%) Link
  13. Yi-Lung Chen, Chang-Ping Yu, Tzong-Huei Lee, King-Siang Goh, Kung-Hui Chu, Po-Hsiang Wang, Wael Ismail, Chao-Jen Shih, and Yin-Ru Chiang*, 2017, “Biochemical Mechanisms and Catabolic Enzymes Involved in Bacterial Estrogen Degradation Pathways”, CHEMISTRY & BIOLOGY, 24, 712-724. (SCIE) (IF: 6.743; SCIE ranking: 11%) Link
  14. Yi-Lung Chen, Chia-Hsiang Wang, Fu-Chun Yang, Wael Ismail, Po-Hsiang Wang, Chao-Jen Shih, Yu-Ching Wu, and Yin-Ru Chiang*, 2016, “Identification of Comamonas testosteroni as an androgen degrader in sewage.”, Scientific Reports, 6, 35386. (SCIE) (IF: 4.259; SCIE ranking: 15.6%) Link
  15. Fu-Chun Yang, Yi-Lung Chen, Sen-Lin Tang, Chang-Ping Yu, Po-Hsiang Wang, Wael Ismail, Chia-Hsiang Wang, Jiun-Yan Ding, Cheng-Yu Yang, Chia-Ying Yang, and Yin-Ru Chiang*, 2016, “Integrated multi-omics analyses reveal the biochemical mechanisms and phylogenetic relevance of anaerobic androgen biodegradation in the environment”, ISME Journal, 10, 1967-1983. (SCIE) (IF: 9.664; SCIE ranking: 2%,5.6%) Link
  16. Jiun-Yan Ding,Jia-Ho Shiu,Wen-Ming Chen, Yin-Ru Chiang, and Sen-Lin Tang, 2016, “Genomic insight into the host-endosymbiont relationship of Endozoicomonas montiporae CL-33 with its coral host.”, Frontiers in Microbiology, 7, 251. (SCIE) (IF: 4.076; SCIE ranking: 20.8%) Link
  17. Ching-Wen Lin, Po-Hsiang Wang, Wael Ismail, Yu-Wen Tsai, Ashraf El Nayal, Chia-Ying Yang, Fu-Chun Yang, Chia-Hsiang Wang, and Yin-Ru Chiang*, 2015, “Substrate uptake and subcellular compartmentation of anoxic cholesterol catabolism in Sterolibacterium denitrificans.”, JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 1155-1169. (SCIE) (IF: 4.011; SCIE ranking: 25.6%) Link
專書(論文集)之一章 ( 2015 - 2020 )
  1. Yin-Ru Chiang* and Wael Ismail, 2017, “Chapter title: Anaerobic biodegradation of steroids”, editor(s): Timmis, Kenneth N, Volume 5: Anaerobic Utilization of Hydrocarbons, Oils and Lipids (Boll, Matthias, ed.), Handbook of Hydrocarbon and Lipid Microbiology Series, pp. 1-32, Berlin Heidelberg, Germany: Springer-Verlag.