江殷儒 副研究員

實驗室主持人

Dr.江殷儒

助研究員

PhD – University of Freiburg, Germany, 2007

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辦公室: 跨領域B305

電話:+886-2-2787-2251

研究領域
  • 微生物代謝多樣性
  • 微生物生理生態
  • 生物降解與生物修復

研究方向

  • 1.固醇類物質之生物降解
    固醇類物質為自然界中種類最繁雜且最常見的有機物質之一,微生物對固醇的降解因此對生物地化循環有重要貢獻。此類四環物質在動物生理乃至微生物-寄主間的交互作用,扮演相當重要且多元的角色,例如肺結核桿菌依賴寄主內的膽固醇作為重要碳源。我們已經解開了雄激素及膽固醇的無氧降解機制,並找到了關鍵性的降解基因與酵素。其中包含眾多前所未見的代謝策略與酵素。目前著眼於雌激素的有氧及無氧降解途徑。由於人類活動、畜牧業,以及製藥產業的排放,自然及人工合成之雌激素物質廣泛存在環境中,且在極低濃度下(1奈克/公升以下),即可干擾動物的生理與行為。本實驗室自汙水處理廠分離出數株雌激素降解細菌,期望能以此作為模式生物,探討雌激素之有氧及無氧降解途徑的生化反應及基因調控機制;進而分析實際在環境中(如汙水處理廠或河川底泥)參與雌激素降解的菌株與主要代謝模式。吾人之研究將可被應用於固醇荷爾蒙的生物降解與移除。此外,參與固醇無氧代謝的新型酵素具有潛在之生技及製藥用途。
  • 2.嗜熱嗜酸紅藻之生理生態研究與硫磺溫泉生態系的藻菌交互作用
    溫泉紅藻是少數生長於酸性溫泉的真核微生物之一,在高達55℃的環境中仍可生長。棲息在這種極端環境的單細胞藻除了進行光合自營作用,也能利用多種有機碳源進行異營生長,具有在酸化的工業廢水中除去有機碳的潛力。此外,溫泉紅藻能夠產生抗氧化的類胡蘿蔔素與藻藍素,在生技產業開發上亦相當具有潛力。儘管溫泉紅藻具有高度的代謝多樣性,但目前關於個體在不同光源強度與外加碳源下的生理調控機制,了解仍非常有限。藉由多重體學技術分析溫泉紅藻在不同培養條件下的生理與代謝反應,我們企圖找出區分自營、異營與混營狀態的分子標誌,作為調查實際環境中溫泉紅藻生理狀態的重要依據。此外,我們利用多重環境體學技術及古典分離培養技術,研究硫磺溫泉生態系的藻相及菌相;並試圖釐清溫泉紅藻與共棲細菌之間的硫代謝及代謝物交換等微生物交互作用。

 

最新發表

期刊論文 ( 2015 - 2018 )

  1. Mei-Chuan Chen, Guei-Jane Wang, Yueh-Hsiung Kuo, Yin-Ru Chiang, Ting-Yu Cho, Yu-Ming Ju, Tzong-Huei Lee*, accepted, “Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata”, JOURNAL OF FOOD AND DRUG ANALYSIS. (SCI) (IF: 3.048; SCI ranking: 32.7%,17.7%) Link
  2. Kan Wu, Tzong-Huei Lee, Yi-Lung Chen, Yu-Sheng Wang, Po-Hsiang Wang, Chang-Ping Yu, Kung-Hui Chu, and Yin-Ru Chiang*, 2018, “Identification of metabolites involved in the aerobic degradation of estrogen A/B-rings”, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 85:e02223-18. (SCI) (IF: 3.807; SCI ranking: 20.6%,23.2%) Link
  3. Sean Ting-Shyang Wei, Yu-Wei Wu, Tzong-Huei Lee, Yi-Shiang Huang, Cheng-Yu Yang, Yi-Lung Chen, and Yin-Ru Chiang*, 2018, “Microbial functional responses to cholesterol catabolism in denitrifying sludge”, mSystems, 3(5), e00113-18. (SCI) Link
  4. Min Lv, Ching Lo, Cheng-Chih Hsu, Yuwen Wang, Yin-Ru Chiang, Qian Sun, Yang Wu, Yan Li, Lingxin Chen, Chang-Ping Yu*, 2018, “Identification of enantiomeric byproducts during microalgae-mediated transformation of metoprolol by MS/MS spectrum-based networking”, FRONTIERS IN MICROBIOLOGY, 9, 2115. (SCI) (IF: 4.076; SCI ranking: 20.8%) Link
  5. Yi-Lung Chen, Han-Yi Fu, Tzong-Huei Lee, Chao-Jen Shih, Lina Huang, Yu-Sheng Wang, Wael Ismail, and Yin-Ru Chiang*, 2018, “Identification of estrogen degradation pathway and estrogen degraders in an activated sludge”, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 84, 84:e00001-18. (SCI) (IF: 3.807; SCI ranking: 20.6%,23.2%) Link
  6. Hisayoshi Nozaki1*, Noriko Ueki, Mari Takusagawa, Shota Yamashita, Osami Misumi, Ryo Matsuzaki, Masanobu Kawachi, Yin-Ru Chiang, and Jiunn-Tzong Wu, 2018, “Morphology, taxonomy and mating-type loci in natural populations of Volvox carteri in Taiwan”, BOTANICAL STUDIES, 59(1), 10. (SCI) (IF: 1.452; SCI ranking: 44.8%) Link
  7. Chao-Jen Shih, Yi-Lung Chen, Chia-Hsiang Wang, Sean Ting-Shyang Wei, I-Ting Lin, Wael Ahmed Ismail, and *Yin-Ru Chiang, 2017, “Biochemical mechanisms and microorganisms involved in anaerobic androgen metabolism in estuarine sediments.”, FRONTIERS IN MICROBIOLOGY, 8, 1520. (SCI) (IF: 4.076; SCI ranking: 20.8%) Link
  8. Yi-Lung Chen, Chang-Ping Yu, Tzong-Huei Lee, King-Siang Goh, Kung-Hui Chu, Po-Hsiang Wang, Wael Ismail, Chao-Jen Shih, and Yin-Ru Chiang*, 2017, “Biochemical Mechanisms and Catabolic Enzymes Involved in Bacterial Estrogen Degradation Pathways”, CHEMISTRY & BIOLOGY, 24, 712-724. (SCI) (IF: 6.743; SCI ranking: 11%) Link
  9. Yi-Lung Chen, Chia-Hsiang Wang, Fu-Chun Yang, Wael Ismail, Po-Hsiang Wang, Chao-Jen Shih, Yu-Ching Wu, and Yin-Ru Chiang*, 2016, “Identification of Comamonas testosteroni as an androgen degrader in sewage.”, Scientific Reports, 6, 35386. (SCI) (IF: 4.259; SCI ranking: 15.6%) Link
  10. Fu-Chun Yang, Yi-Lung Chen, Sen-Lin Tang, Chang-Ping Yu, Po-Hsiang Wang, Wael Ismail, Chia-Hsiang Wang, Jiun-Yan Ding, Cheng-Yu Yang, Chia-Ying Yang, and Yin-Ru Chiang*, 2016, “Integrated multi-omics analyses reveal the biochemical mechanisms and phylogenetic relevance of anaerobic androgen biodegradation in the environment”, ISME Journal, 10, 1967-1983. (SCI) (IF: 9.664; SCI ranking: 2%,5.6%) Link
  11. Jiun-Yan Ding,Jia-Ho Shiu,Wen-Ming Chen, Yin-Ru Chiang, and Sen-Lin Tang, 2016, “Genomic insight into the host-endosymbiont relationship of Endozoicomonas montiporae CL-33 with its coral host.”, Frontiers in Microbiology, 7, 251. (SCI) (IF: 4.076; SCI ranking: 20.8%) Link
  12. Ching-Wen Lin, Po-Hsiang Wang, Wael Ismail, Yu-Wen Tsai, Ashraf El Nayal, Chia-Ying Yang, Fu-Chun Yang, Chia-Hsiang Wang, and Yin-Ru Chiang*, 2015, “Substrate uptake and subcellular compartmentation of anoxic cholesterol catabolism in Sterolibacterium denitrificans.”, JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 1155-1169. (SCI) (IF: 4.125; SCI ranking: 25.5%) Link
專書(論文集)之一章 ( 2015 - 2018 )
  1. *Yin-Ru Chiang and Wael Ismail, 2017, “Chapter title: Anaerobic biodegradation of steroids”, editor(s): Timmis, Kenneth N, Volume 5: Anaerobic Utilization of Hydrocarbons, Oils and Lipids (Boll, Matthias, ed.), Handbook of Hydrocarbon and Lipid Microbiology Series, pp. 1-32, Berlin Heidelberg, Germany: Springer-Verlag.

實驗室成員

博士後研究及助理
研究生及其他人員
辦公室位置
電  話

傅翰儀     陳宜龍     魏廷翔

高麗珠     黃翊翔     王郁盛  

李芊穎     李語珊     張雅鈞

跨領域B305

2787-2252