江殷儒 副研究員

實驗室主持人

Dr.江殷儒

副研究員

PhD – University of Freiburg, Germany, 2007

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辦公室: 跨領域B305

電話:+886-2-2787-2251

研究領域
  • 微生物代謝多樣性
  • 生物降解與生物修復
  • 微生物之生理生態研究
  • 環境體學分析

研究方向

  • 1.探討維生素B12在厭氧微生物交互作用所扮演的角色
      維生素B12及其相關化合物為自然界中結構最複雜且種類最繁雜的維生素,其參與許多基礎的生物代謝,包括胺基酸、核酸及脂肪酸的生合成。另外,許多重要的生物地化循環,包括碳、鹵素及重金屬依賴維生素B12作為輔脢來推動。幾乎地球上所有的生物都需要維生素B12;然而,僅有少數的原核生物具有生合成維生素B12的能力。這個神奇的含鈷化合物因此成為極其重要的戰略資源,在生物間的交互作用中扮演重要角色;經由食物鏈傳遞,進而影響生物群落的結構與功能。好氧生態系的維生素B12類群僅有鈷胺素(cobalamins)及偽鈷胺素(pseudocobalamins)兩種。在厭氧生態系,維生素B12類群的結構與功能的多樣性極高,已知至少存在有17種以上的不同結構。目前仍不清楚,這些結構互異的維生素在厭氧生態系所扮演的角色。我們試圖探討以下數個與維生素B12類群有關的研究課題:(i)厭氧微生物如何經由交互作用來合成、運輸及代謝維生素B12;(ii) 維生素B12如何影響厭氧微生物的群落結構;(iii) 維生素B12是否對於C1代謝及環境荷爾蒙之厭氧降解具有重要性;以及(iv)何以厭氧微生物製造如此多樣的維生素B12結構。
  • 2.重要環境荷爾蒙的生物降解

      雌激素及塑化劑(PAEs)被視為主要的環境荷爾蒙,在極低濃度下,即可對周遭的動物(包括人類)的生理、發育、代謝及生殖產生長遠且重大的影響。這些物質在環境中的分佈、持久性以及代謝命運,因此受到科學界與公眾的關注。隨著都市化以及全球化的腳步,這些環境荷爾蒙幾乎可以在地球上的任何角落,包括極地與深海被偵測到。由於其強烈的親脂性,這些環境荷爾蒙很容易被土壤及底泥所吸附,而大量累積於缺氧環境之中。微生物降解被視為移除這些環境荷爾蒙的主要機制。然而,僅有極少數的厭氧微生物可以分解這些頑強的化合物。此外,我們對於相關的厭氧降解機制與酵素,所知仍然極其有限。我們目前著眼於雌激素及塑化劑DEHP的無氧降解機制。本實驗室自汙水處理廠及河口底泥分離出數株雌激素及塑化劑降解細菌,期望能以此作為模式生物,探討無氧降解途徑的生化反應及基因調控機制;進而分析在缺氧環境中(如汙水處理廠或河川底泥)參與環境荷爾蒙降解的細菌種類與主要代謝模式。吾人之研究將可被應用於環境荷爾蒙的生物降解與移除。此外,相關的新型酵素具有潛在之生技及製藥用途。

 

最新發表

期刊論文 ( 2016 - 2019 )

  1. Po-Hsiang Wang, Yi-Lung Chen, Sean Ting-Shyang Wei, Kan Wu, Tzong-Huei Lee, Tien-Yu Wu, and Yin-Ru Chiang*, accepted, “Retroconversion of estrogens into androgens by bacteria via a cobalamin-mediated methylation”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. (SCI) (IF: 9.504; SCI ranking: 7.8%)
  2. Yin-Ru Chiang*, Sean Ting-Shyang Wei, Po-Hsiang Wang, Pei-Hsun Wu, Chang-Ping Yu, accepted, “Microbial degradation of steroid sex hormones: Implications for environmental and ecological studies.”, MICROBIAL BIOTECHNOLOGY, DOI: 10.1111/1751-7915.13504. (SCI) (IF: 3.913; SCI ranking: 20.5%,27%) Link
  3. Mei-Chuan Chen, Guei-Jane Wang, Yueh-Hsiung Kuo, Yin-Ru Chiang, Ting-Yu Cho, Yu-Ming Ju, Tzong-Huei Lee*, accepted, “Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata”, JOURNAL OF FOOD AND DRUG ANALYSIS, 27(1),111-117. (SCI) (IF: 3.048; SCI ranking: 32.7%,17.7%) Link
  4. Kan Wu, Tzong-Huei Lee, Yi-Lung Chen, Yu-Sheng Wang, Po-Hsiang Wang, Chang-Ping Yu, Kung-Hui Chu, and Yin-Ru Chiang*, 2019, “Metabolites Involved in Aerobic Degradation of the A and B Rings of Estrogen”, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 85(3), e02223-18. (SCI) (IF: 3.807; SCI ranking: 20.6%,23.2%) Link
  5. Sean Ting-Shyang Wei, Yu-Wei Wu, Tzong-Huei Lee, Yi-Shiang Huang, Cheng-Yu Yang, Yi-Lung Chen, and Yin-Ru Chiang*, 2018, “Microbial functional responses to cholesterol catabolism in denitrifying sludge”, mSystems, 3(5), e00113-18. (SCI) Link
  6. Min Lv, Ching Lo, Cheng-Chih Hsu, Yuwen Wang, Yin-Ru Chiang, Qian Sun, Yang Wu, Yan Li, Lingxin Chen, Chang-Ping Yu*, 2018, “Identification of enantiomeric byproducts during microalgae-mediated transformation of metoprolol by MS/MS spectrum-based networking”, FRONTIERS IN MICROBIOLOGY, 9, 2115. (SCI) (IF: 4.076; SCI ranking: 20.8%) Link
  7. Yi-Lung Chen, Han-Yi Fu, Tzong-Huei Lee, Chao-Jen Shih, Lina Huang, Yu-Sheng Wang, Wael Ismail, and Yin-Ru Chiang*, 2018, “Identification of estrogen degradation pathway and estrogen degraders in an activated sludge”, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 84, 84:e00001-18. (SCI) (IF: 3.807; SCI ranking: 20.6%,23.2%) Link
  8. Hisayoshi Nozaki1*, Noriko Ueki, Mari Takusagawa, Shota Yamashita, Osami Misumi, Ryo Matsuzaki, Masanobu Kawachi, Yin-Ru Chiang, and Jiunn-Tzong Wu, 2018, “Morphology, taxonomy and mating-type loci in natural populations of Volvox carteri in Taiwan”, BOTANICAL STUDIES, 59(1), 10. (SCI) (IF: 1.452; SCI ranking: 44.8%) Link
  9. Chao-Jen Shih, Yi-Lung Chen, Chia-Hsiang Wang, Sean Ting-Shyang Wei, I-Ting Lin, Wael Ahmed Ismail, and *Yin-Ru Chiang, 2017, “Biochemical mechanisms and microorganisms involved in anaerobic androgen metabolism in estuarine sediments.”, FRONTIERS IN MICROBIOLOGY, 8, 1520. (SCI) (IF: 4.076; SCI ranking: 20.8%) Link
  10. Yi-Lung Chen, Chang-Ping Yu, Tzong-Huei Lee, King-Siang Goh, Kung-Hui Chu, Po-Hsiang Wang, Wael Ismail, Chao-Jen Shih, and Yin-Ru Chiang*, 2017, “Biochemical Mechanisms and Catabolic Enzymes Involved in Bacterial Estrogen Degradation Pathways”, CHEMISTRY & BIOLOGY, 24, 712-724. (SCI) (IF: 6.743; SCI ranking: 11%) Link
  11. Yi-Lung Chen, Chia-Hsiang Wang, Fu-Chun Yang, Wael Ismail, Po-Hsiang Wang, Chao-Jen Shih, Yu-Ching Wu, and Yin-Ru Chiang*, 2016, “Identification of Comamonas testosteroni as an androgen degrader in sewage.”, Scientific Reports, 6, 35386. (SCI) (IF: 4.259; SCI ranking: 15.6%) Link
  12. Fu-Chun Yang, Yi-Lung Chen, Sen-Lin Tang, Chang-Ping Yu, Po-Hsiang Wang, Wael Ismail, Chia-Hsiang Wang, Jiun-Yan Ding, Cheng-Yu Yang, Chia-Ying Yang, and Yin-Ru Chiang*, 2016, “Integrated multi-omics analyses reveal the biochemical mechanisms and phylogenetic relevance of anaerobic androgen biodegradation in the environment”, ISME Journal, 10, 1967-1983. (SCI) (IF: 9.664; SCI ranking: 2%,5.6%) Link
  13. Jiun-Yan Ding,Jia-Ho Shiu,Wen-Ming Chen, Yin-Ru Chiang, and Sen-Lin Tang, 2016, “Genomic insight into the host-endosymbiont relationship of Endozoicomonas montiporae CL-33 with its coral host.”, Frontiers in Microbiology, 7, 251. (SCI) (IF: 4.076; SCI ranking: 20.8%) Link
專書(論文集)之一章 ( 2016 - 2019 )
  1. *Yin-Ru Chiang and Wael Ismail, 2017, “Chapter title: Anaerobic biodegradation of steroids”, editor(s): Timmis, Kenneth N, Volume 5: Anaerobic Utilization of Hydrocarbons, Oils and Lipids (Boll, Matthias, ed.), Handbook of Hydrocarbon and Lipid Microbiology Series, pp. 1-32, Berlin Heidelberg, Germany: Springer-Verlag.