王子元 研究副技師

實驗室主持人

Dr.王子元

研究副技師

國立清華大學博士, 2004

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辦公室: 跨領域 C204

電話:+886-2-2787-2258

研究領域
  • 酵母菌基因調控演化
  • 生質能源之體學應用
  • 動物感覺基因的適應演化
  • 淡水魚類之親緣地理學

研究方向

  • 1.酵母菌基因調控機制之演化
    基因調控機制分為順式與反式調控兩種。順式調控子係指在基因啟動子區域的片段DNA序列,反式調控子則是指調控蛋白。轉錄體學研究發現酵母菌種內的順式調控機制亦不少,唯反式調控機制還是較常出現。與酵母菌種間的調控機制比較,在基因表現的演化過程中,順式調控在演化上受到正向選擇影響較大,反式調控機制在演化上則受到負向選擇影響較多。
  • 2.酵母菌有氧醱酵之演化
    透過基因體學比較不同酵母菌從無氧醱酵到有氧醱酵的演化過程。研究發現與有氧呼吸作用相關的粒線體基因表現量偏低,而這類基因群在有氧醱酵的酵母菌種中,多半失去Cbf1順式調控子的位點。進一步研究與醱酵相關的基因群將有助於建立酵母菌有氧醱酵之演化學說。
  • 3.魚類感覺基因的比較轉錄體學
    透過比較洄游性魚類的視覺與嗅覺基因表現對環境的適應演化,將有助於瞭解魚類的洄游行為及其生理反應。

 

最新發表

期刊論文 ( 2015 - 2018 )

  1. Chang TS, Wu JY, Wang TY, Wu KY, Chiang CM*, 2018, “Uridine Diphosphate-Dependent Glycosyltransferases from Bacillus subtilis ATCC 6633 Catalyze the 15-O-Glycosylation of Ganoderic Acid A”, International Journal of Molecular Sciences, 19(11), 3469. (SCI) (IF: 3.226; SCI ranking: 40.3%,32.5%) Link
  2. Tseng WH, Lin JW, Lou CH, Lee KH, Wu LS, Wang TY, Wang FY*, Irschick DJ, Lin SM*, 2018, “Opsin gene expression regulated by testosterone level in a sexually dimorphic lizard”, Scientific Reports, 8:16055. (SCI) (IF: 4.259; SCI ranking: 15.6%) Link
  3. Chang TS, Chiang CM, Wang TY, Lee CH, Lee YW, Wu JY*, 2018, “New Triterpenoid from Novel Triterpenoid 15-O-Glycosylation on Ganoderic Acid A by Intestinal Bacteria of Zebrafish”, Molecules, 23(9), 2345. (SCI) (IF: 2.861; SCI ranking: 28.8%) Link
  4. Chiang CM, Wang TY, Yang SY, Wu JY*, Chang TS*, 2018, “Production of New Isoflavone Glucosides from Glycosylation of 8-Hydroxydaidzein by Glycosyltransferase from Bacillus subtilis ATCC 6633”, Catalysts, 8(9), 387. (SCI) (IF: 3.082; SCI ranking: 36.3%) Link
  5. Lee MH, Lin JJ, Lin YJ, Chang JJ, Ke HM, Fan WL, Wang TY, Li WH*, 2018, “Genome-wide prediction of CRISPR/Cas9 targets in Kluyveromyces marxianus and its application to obtain a stable haploid strain”, Scientific Reports, 8(1), 7305. (SCI) (IF: 4.259; SCI ranking: 15.6%) Link
  6. Huang SP, Wang FY, Wang TY*, 2017, “Molecular phylogeny of the Opsariichthys group (Teleostei: Cypriniformes) based on complete mitochondrial genomes”, Zoological Studies, 56, 40. (SCI) (IF: 1.008; SCI ranking: 52.1%) Link
  7. Lin JJ, Wang FY, Li WH*, Wang TY*, 2017, “The rises and falls of opsin genes in 59 ray-finned fish genomes and their implications for environmental adaptation”, SCIENTIFIC REPORTS, 7(1), 15568. (SCI) (IF: 4.259; SCI ranking: 15.6%) Link
  8. Chiang CM, Wang TY, Ke AN, Chang TS*, Wu JY*, 2017, “Biotransformation of Ergostane Triterpenoid Antcin K from Antrodia cinnamomea by Soil-Isolated Psychrobacillus sp. AK 1817”, CATALYSTS, 7(10), 299. (SCI) (IF: 3.082; SCI ranking: 36.3%) Link
  9. Bhattacharjee MJ, Yu CP, Lin JJ, Ng CS, Wang TY, Lin HH, Li WH*, 2016, “Regulatory divergence among beta-keratin genes during bird evolution”, Molecular Biology and Evolution, 33(11), 2769-2780. (SCI) (IF: 6.202; SCI ranking: 12.8%,9%,10.4%) Link
  10. Wang TY, Tsai YH, Yu IZ, Chang TS*, 2016, “Improving 3'-hydroxygenistein production in recombinant Pichia pastoris by a periodic hydrogen peroxide-shocking strategy”, Journal of Microbiology and Biotechnology, 26(3), 498-502. (SCI) (IF: 1.75; SCI ranking: 60.6%,70.4%) Link
  11. Wang TY*, 2015, “Engineering yeast for cellulosic ethanol production”, Austin Chemical Engineering, 2(2), 1018. Link
  12. Wang FY, Wang TY, Liao TY, Liu MY*, 2015, “The complete mitochondrial genome sequence of Nemateleotris decora (gobiiformes, gobiidae)”, Mitochondrial DNA Part A, 27(6), 4274-4275. Link
  13. Schaefke B, Wang TY, Wang CY, Li WH*, 2015, “Gains and losses of transcription factor binding sites in Saccharomyces cerevisiae and S. paradoxus”, Genome Biology and Evolution, 7(8), 2245-2257. (SCI) (IF: 3.979; SCI ranking: 25.1%,29.2%) Link