I am Distinguished Research Fellow at the Biodiversity Research Center, Academia Sinica (BRCAS) in Taipei. Before moving back to Taiwan in 2013, I was the James Watson Professor, Department of Ecology and Evolution, University of Chicago.
I received my PhD in applied mathematics, but have been working on evolutionary biology since my graduate study. My research interests are population genetics, bioinformatics, molecular evolution, and genomic evolution.

期刊論文

1. Wu CC, Hsieh KT, Yeh SY, Lu YT, Chen LJ, Ku MSB, Li WH*, 2023, “Simultaneous detection of miRNA and mRNA at the single-cell level in plant tissues.”, Plant biotechnology journal, 21, 36-149. (SCIE) (IF: 13.263; SCI ranking: 5%,2.1%)
2. Pi HW, Lin JJ, Chen CA, Wang PH, Chiang YR, Huang CC, Young CC, Li WH*, 2022, “Origin and Evolution of Nitrogen Fixation in Prokaryotes”, Molecular biology and evolution, 39(9), msac181. (SCIE) (IF: 8.8; SCI ranking: 13.1%,9.6%,8.5%)
3. Samuel SY, Wang HD, Huang MY, Cheng YS, Chen JR, Li WH, Chang JJ, 2022, “Safety Assessment of 3S, 3'S Astaxanthin Derived from Metabolically Engineered K. marxianus.”, Antioxidants, 11(11), 1-16. (SCIE) (IF: 7.675; SCI ranking: 16.8%,6.3%,8.3%)
4. Lo KL, Chen YN, Chiang MY, Chen MC, Panibe JP, Chiu CC, Liu LW, Chen LJ, Chen CW, Li WH, Wang CS, 2022, “Two genomic regions of a sodium azide induced rice mutant confer broad-spectrum and durable resistance to blast disease.”, Rice, 15(1), 2. (SCIE) (IF: 5.638; SCI ranking: 12.2%)
5. Liu WY, Yu CP, Chang CK, Chen HJ, Li MY, Chen YH, Shiu SH, Ku MSB, Tu SL, Lu MJ, Li WH*, 2022, “Regulators of early maize leaf development inferred from transcriptomes of laser capture microdissection (LCM)-isolated embryonic leaf cells.”, Proceedings of the National Academy of Sciences of the United States of America, 119(35), e2208795119. (SCIE) (IF: 12.779; SCI ranking: 12.2%)
6. Panibe JP, Wang L, Lee YC, Wang CS, Li WH, 2022, “Identifying mutations in sd1, Pi54 and Pi-ta, and positively selected genes of TN1, the first semidwarf rice in Green Revolution.”, Botanical studies, 63(1), 9. (SCIE) (IF: 2.673; SCI ranking: 40.8%)
7. Ng CS, Lai CK, Ke HM, Lee HH, Chen CF, Tang PC, Cheng HC, Lu MJ, Li WH, Tsai IJ, 2022, “Genome Assembly and Evolutionary Analysis of the Mandarin Duck Aix galericulata Reveal Strong Genome Conservation among Ducks”, Genome biology and evolution, 14(6), evac083. (SCIE) (IF: 4.065; SCI ranking: 32.7%,41.2%)
8. Tusher TR, Chang JJ, Saunivalu MI, Wakasa S, Li WH, Huang CC, Inoue C, Chien MF, 2022, “Second-generation bioethanol production from phytomass after phytoremediation using recombinant bacteria-yeast co-culture”, Fuel, 326, 124975-124975. (SCIE) (IF: 8.035; SCI ranking: 24.4%,13.3%)
9. Su-Ying Y, Lin HH, Chang YM, Chang YL, Chang CK, Huang YC, Ho YW, Lin CY, Zheng JZ, Jane WN, Ng CY, Lu MY, Lai IL, To KY, Li WH, Ku MSB, 2022, “Maize Golden2-like transcription factors boost rice chloroplast development, photosynthesis and grain yield.”, Plant physiology, 188(1), 442-459. (SCIE) (IF: 8.005; SCI ranking: 5%)
10. Huang CF, Liu WY, Lu MYJ, Chen YH, Ku MSB, Li WH*, 2021, “Whole genome duplication facilitated the evolution of C4 photosynthesis in Gynandropsis gynandra”, Molecular biology and evolution, 38 (11) , 4715-4731. (SCIE) (IF: 8.8; SCI ranking: 13.1%,9.6%,8.5%)
11. Ko SS, Li MJ, Ho YC, Yu CP, Yang TT, Lin YJ, Hsing HC, Chen TK, Jhong CM, Li WH, Sun-Ben Ku M, 2021, “Rice transcription factor GAMYB modulates bHLH142 and is homeostatically regulated by TDR during anther tapetal and pollen development”, Journal of experimental botany, 72(13), 4888-4903. (SCIE) (IF: 7.378; SCI ranking: 6.3%)
12. Yu CP, Kuo CH, Nelson CW, Chen CA, Soh ZT, Lin JJ, Hsiao RX, Chang CY, Li WH*, 2021, “Discovering unknown human and mouse transcription factor binding sites and their characteristics from ChIP-seq data.”, Proceedings of the National Academy of Sciences of the United States of America, 118(20), e2026754118. (SCIE) (IF: 12.779; SCI ranking: 12.2%)
13. Joyraj Bhattacharjee M, Lin JJ, Chang CY, Chiou YT, Li TN, Tai CW, Shiu TF, Chen CA, Chou CY, Chakraborty P, Yuan Tseng Y, Hui-Ching Wang L, Li WH*, 2021, “Identifying primate ACE2 variants that confer resistance to SARS-CoV-2.”, Molecular biology and evolution, 38(7), 2715–2731. (SCIE) (IF: 8.8; SCI ranking: 13.1%,9.6%,8.5%)
14. Liu HL, Wang CH, Chiang EI, Huang CC, Li WH*, 2021, “Tryptophan plays an important role in yeast's tolerance to isobutanol.”, Biotechnology for biofuels, 14(1), 200. (SCIE) (IF: 7.67; SCI ranking: 11.8%,26.1%)
15. Panibe JP, Wang L, Li JY, Li MY, Lee YC, Wang CS, Ku MSB, Lu MY, Li WH*, 2021, “Chromosomal-level genome assembly of the semi-dwarf rice Taichung Native 1, an initiator of Green Revolution”, Genomics, 113(4), 2656-2674. (SCIE) (IF: 4.31; SCI ranking: 36.6%,33.9%)
16. Liu Wen-Yu, Lin Hsin-Hung, Yu Chun-Ping, Chang Chao-Kang, Chen Hsiang-June, Lin Jinn-Jy, Lu Mei-Yeh Jade, Tu Shih-Long, Shiu Shin-Han, Wu Shu-Hsing, Ku Maurice S. B., Li Wen-Hsiung*, 2020, “Maize ANT1 modulates vascular development, chloroplast development, photosynthesis, and plant growth”, Proceedings of the National Academy of Sciences of the United States of America, 117(35), 21747-21756. (SCIE) (IF: 12.779; SCI ranking: 12.2%)
17. Vu Trieu-Duc, Iwasaki Yuki, Shigenobu Shuji, Maruko Akiko, Oshima Kenshiro, Iioka Erica, Huang Chao-Li, Abe Takashi, Tamaki Satoshi, Lin Yi-Wen, Chen Chih-Kuan, Lu Mei-Yeh, Hojo Masaru, Wang Hao-Ven, Tzeng Shun-Fen, Huang Hao-Jen, Kanai Akio, Gojobori Takashi, Chiang Tzen-Yuh, Sun H. Sunny, Li Wen-Hsiung, Okada Norihiro, 2020, “Behavioral and brain- transcriptomic synchronization between the two opponents of a fighting pair of the fish Betta splendens”, PLoS Genetics, 16(6), e1008831. (SCIE) (IF: 6.02; SCI ranking: 15.3%)
18. Lee MH, Hsu TL, Lin JJ, Lin YJ, Kao YY, Chang JJ, Li WH*, 2020, “Constructing a human complex type N-linked glycosylation pathway in Kluyveromyces marxianus.”, PloS one, 15(5), e0233492. (SCIE) (IF: 3.752; SCI ranking: 39.2%)
19. Anandharaj M, Lin YJ, Rani RP, Nadendla EK, Ho MC, Huang CC, Cheng JF, Chang JJ, Li WH*, 2020, “Constructing a yeast to express the largest cellulosome complex on the cell surface.”, Proceedings of the National Academy of Sciences of the United States of America, 117(5), 2385-2394. (SCIE) (IF: 12.779; SCI ranking: 12.2%)
20. Wang WF, Lu MJ, Cheng TR, Tang YC, Teng YC, Hwa TY, Chen YH, Li MY, Wu MH, Chuang PC, Jou R, Wong CH, Li WH*, 2020, “Genomic Analysis of Mycobacterium tuberculosis Isolates and Construction of a Beijing Lineage Reference Genome.”, Genome biology and evolution, 12(2), 3890-3905. (SCIE) (IF: 4.065; SCI ranking: 32.7%,41.2%)
21. Wang L, Zhao L, Zhang X, Zhang Q, Jia Y, Wang G, Li S, Tian D, Li WH*, Yang S, 2019, “Large-scale identification and functional analysis of NLR genes in blast resistance in the Tetep rice genome sequence.”, Proceedings of the National Academy of Sciences of the United States of America, 116(37), 18479-18487. (SCIE) (IF: 12.779; SCI ranking: 12.2%)
22. Liu HL, Chang JJ, Thia C, Lin YJ, Lo SC, Huang CC, Li WH*, 2019, “Characterizing an engineered carotenoid-producing yeast as an anti-stress chassis for building cell factories.”, Microbial cell factories, 18(1), 155. (SCIE) (IF: 6.352; SCI ranking: 16.8%)
23. Gomez Luciano LB, Jason Tsai I, Chuma I, Tosa Y, Chen YH, Li JY, Li MY, Jade Lu MY, Nakayashiki H, Li WH*, 2019, “Blast fungal genomes show frequent chromosomal changes, gene gains and losses, and effector gene turnover.”, Molecular biology and evolution, 36(6),1148-1161. (SCIE) (IF: 8.8; SCI ranking: 13.1%,9.6%,8.5%)
24. Chang YM, Lin HH, Liu WY, Yu CP, Chen HJ, Wartini PP, Kao YY, Wu YH, Lin JJ, Lu MJ, Tu SL, Wu SH, Shiu SH, Ku MSB, Li WH*, 2019, “Comparative transcriptomics method to infer gene coexpression networks and its applications to maize and rice leaf transcriptomes.”, Proceedings of the National Academy of Sciences of the United States of America, 116(8), 3091-3099. (SCIE) (IF: 12.779; SCI ranking: 12.2%)
25. Lin JJ, Bhattacharjee MJ, Yu CP, Tseng YY, Li WH*, 2019, “Many human RNA viruses show extraordinarily stringent selective constraints on protein evolution.”, Proceedings of the National Academy of Sciences of the United States of America, 116(38), 19009-19018. (SCIE) (IF: 12.779; SCI ranking: 12.2%)
26. Huang CJ, Lu MY, Chang YW, Li WH*, 2018, “Experimental evolution of yeast for high temperature tolerance.”, Molecular biology and evolution, 35(8), 1823-1839. (SCIE) (IF: 8.8; SCI ranking: 13.1%,9.6%,8.5%)
27. Huang J, Li J, Zhou J, Wang L, Yang S, Hurst LD, Li WH, Tian D, 2018, “Identifying a large number of high-yield genes in rice by pedigree analysis, whole-genome sequencing, and CRISPR-Cas9 gene knockout.”, Proceedings of the National Academy of Sciences of the United States of America, 115(32), E7559-E7567. (SCIE) (IF: 12.779; SCI ranking: 12.2%)
28. Pi HW, Anandharaj M, Kao YY, Lin YJ, Chang JJ, Li WH, 2018, “Engineering the oleaginous red yeast Rhodotorula glutinis for simultaneous beta-carotene and cellulase production.”, Scientific reports, 8(1), 10850. (SCIE) (IF: 4.997; SCI ranking: 25.7%)
29. Chang JJ, Anandharaj M, Ho CY, Tsuge K, Tsai TY, Ke HM, Lin YJ, Ha Tran MD, Li WH*, Huang CC, 2018, “Biomimetic strategy for constructing Clostridium thermocellum cellulosomal operons in Bacillus subtilis.”, Biotechnology for biofuels, 11, 157. (SCIE) (IF: 7.67; SCI ranking: 11.8%,26.1%)
30. Lee MH, Lin JJ, Lin YJ, Chang JJ, Ke HM, Fan WL, Wang TY, Li WH*, 2018, “Genome-wide prediction of CRISPR/Cas9 targets in Kluyveromyces marxianus and its application to obtain a stable haploid strain.”, Scientific reports, 8(1), 7305. (SCIE) (IF: 4.997; SCI ranking: 25.7%)
31. Chang JJ, Lin YJ, Lay CH, Thia C, Wu YC, Hou YH, Huang CC, Li WH, 2018, “Constructing a cellulosic yeast host with an efficient cellulase cocktail.”, Biotechnology and bioengineering, 115(3), 751-761. (SCIE) (IF: 4.395; SCI ranking: 34.8%)
32. Wu P, Yan J, Lai YC, Ng CS, Li A, Jiang X, Elsey RM, Widelitz R, Bajpai R, Li WH, Chuong CM, 2018, “Multiple regulatory modules are required for scale-to-feather conversion.”, Molecular biology and evolution, 35(2), 417-430. (SCIE) (IF: 8.8; SCI ranking: 13.1%,9.6%,8.5%)