厭氧及極端微生物、微生物代謝多樣性、微生物之生理生態研究、環境體學分析

我的主要研究興趣是微生物代謝多樣性。目前著重於極端微生物的生理與代謝研究。極端微生物是偏好在極端環境中生長繁殖的一群微生物，通常爲單細胞原核或真核生物。極端環境係指不適合脊椎動物生活之環境，包括缺乏氧氣、極端溫度、極端酸鹼值或是高鹽度等特殊理化條件。伴隨新興微生物分析技術之興起，極端微生物之親緣及代謝多樣性研究，近來獲得許多重大進展。相關之微生物乃至酵素或代謝物，具有相當之生醫、農業與工業應用潛力。

期刊論文

1. Tsun-Hsien Hsiao, Po-Hao Chen, Po-Hsiang Wang, Guo-Jie Brandon-Mong, Chen-Wei Li, Masae Horinouchi, Toshiaki Hayashi, Wael Ismail, Menghsiao Meng, Yi-Lung Chen, Yin-Ru Chiang*, 2023, “Harnessing microbial phylum-specific molecular markers for assessment of environmental estrogen degradation”, SCIENCE OF THE TOTAL ENVIRONMENT, 896, 165152. (SCIE) (IF: 10.754; SCI ranking: 9.3%)
2. Ma LS*, Lin YH, Xu MY, Hsu CC, Lee HC, Tsai WL, Damei F, Hoang C, Chiang YR, 2023, “Ustilago maydis PR-1-like protein has evolved two distinct domains for dual virulence activities”, Nature Communications, 14, 5755. (SCIE) (IF: 17.694; SCI ranking: 8.1%)
3. Gicana RG, Huang MH, Jia TZ, Chiang YR, *Wang PH, 2023, “Upcycling soybean pulp for sustainable amino acid and subsequent protein biomanufacturing via a one-pot thermophilic protease cascade treatment”, CHEMICAL ENGINEERING JOURNAL, 474, 145925. (SCIE) (IF: 16.744; SCI ranking: 2.8%,3.6%)
4. Tsun-Hsien Hsiao, Chia-Hong Chou, Yi-Lung Chen, Po-Hsiang Wang, Guo-Jie Brandon-Mong, Tzong-Huei Lee, Tien-Yu Wu, Po-Ting Li, Chen-Wei Li, Yi-Li Lai, Yu-Lin Tseng, Chao-Jen Shih, Po-Hao Chen, Mei-Jou Chenb, Yin-Ru Chiang*, 2023, “Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut”, GUT MICROBES, 15, 2183685. (SCIE) (IF: 9.434; SCI ranking: 16.1%,13.8%)
5. Huang E, Yan JS, Gicana RG, Chiang YR, Yeh FI, Huang CC, Wang PH*, 2023, “Valorization of soybean pulp for sustainable α-ketoisocaproate production using engineered Bacillus subtilis whole-cell biocatalyst”, CHEMOSPHERE, 322, 138200. (SCIE) (IF: 8.943; SCI ranking: 11.8%)
6. Pi HW, Lin JJ, Chen CA, Wang PH, Chiang YR, Huang CC, Young CC, *Li WH, 2022, “Origin and evolution of nitrogen fixation in prokaryotes”, MOLECULAR BIOLOGY AND EVOLUTION, 39, msac181. (SCIE) (IF: 8.8; SCI ranking: 13.1%,9.6%,8.5%)
7. Hsiao G, Chi WC, Chang CH, Chiang YR, Fu YJ, *Lee TH, 2022, “Bioactive pulvinones from a marine algicolous fungus Aspergillus terreus NTU243”, PHYTOCHEMISTRY, 200, 113229. (SCIE) (IF: 4.004; SCI ranking: 54.2%,22.1%)
8. Wang PH, Chen YL, Wu TY, Wu YW, Wang TY, Shih CJ, Wei STS, Lai YL, Liu CX, Yu CP, Chiang YR*, 2022, “Omics and mechanistic insights into di-(2-ethylhexyl) phthalate degradation in the O2-fluctuating estuarine sediments.”, CHEMOSPHERE, 299, 134406. (SCIE) (IF: 8.943; SCI ranking: 11.8%)
9. Gicana RG, Yeh FI, Hsiao TH, Chiang YR, Yan JS, *Wang PH, 2022, “Valorization of fish waste and sugarcane bagasse for enzyme production by Bacillus megaterium via a circular bioeconomy model”, JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS, 135, 104358. (SCIE) (IF: 5.477; SCI ranking: 23.8%)
10. AlDhafiri S, Chiang YR, EL Nayal AM, Abed RMM, Abotalib N, *Wael Ismail, 2022, “Temporal Compositional Shifts in an Activated Sludge Microbiome during Estrone Biodegradation.”, Environmental Science and Pollution Research, 29, 32702-32716. (SCIE) (IF: 5.19; SCI ranking: 31.2%)
11. Tsun-Hsien Hsiao, Tzong-Huei Lee, Meng-Rong Chuang, Po-Hsiang Wang, Menghsiao Meng, Masae Horinouchi, Toshiaki Hayashi, Yi-Lung Chen, and Yin-Ru Chiang*, 2022, “Identification of essential β-oxidation genes and corresponding metabolites for estrogen degradation by actinobacteria.”, MICROBIAL BIOTECHNOLOGY, 15, 949-966. (SCIE) (IF: 6.575; SCI ranking: 14.3%,21%)
12. Chang CW, Miki T, Ye H, Souissi S, Adrian R, Anneville O, Be'eri-Shlevin Y, Chiang YR, Feuchtmayr H, Ichise S, Kagami M, *Hsieh CH, 2022, “Causal networks of phytoplankton diversity and production are modulated by environmental context.”, NATURE COMMUNICATIONS, 13, 1140. (SCIE) (IF: 17.694; SCI ranking: 8.1%)
13. Sean Ting-Shyang Wei, Yi-Lung Chen, Yu-Wei Wu, Tien-Yu Wu, Yi-Li Lai, Po-Hsiang Wang, Wael Ismail, Tzong-Huei Lee, and Yin-Ru Chiang*, 2021, “Integrated multi-omics investigations reveal the key role of synergistic microbial networks in removing plasticizer di-(2-ethylhexyl) phthalate from estuarine sediments.”, MSYSTEMS, 6, e00358-21. (SCIE) (IF: 7.328; SCI ranking: 19.6%)
14. Wei-Sheng Huang, Li-Ting Wang, Jwo-Sheng Chen, Yen-Ting Chen, Sean Ting-Shyang Wei, Yin-Ru Chiang, Pei-Ling Wang, Tzong-Huei Lee, Shih-Ting Lin, Lina Huang, Wung Yang Shieh*, 2021, “Vibrio nitrifigilis sp. nov., a marine nitrogen-fixing bacterium isolated from the lagoon sediment of an islet inside an atoll”, ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 114, 933-945. (SCIE) (IF: 2.158; SCI ranking: 87.7%)
15. Tsun-Hsien Hsiao, Yi-Lung Chen, Menghsiao Meng, Meng-Rong Chuang, Masae Horinouchi, Toshiaki Hayashi, Po-Hsiang Wang, and Yin-Ru Chiang*, 2021, “Mechanistic and phylogenetic insights into actinobacteria-mediated estrogen biodegradation in urban estuarine sediments”, MICROBIAL BIOTECHNOLOGY, 13, 926-949. (SCIE) (IF: 6.575; SCI ranking: 14.3%,21%)
16. Chun-Wei Chang, Hao Ye, Takeshi Miki, Ethan R Deyle, Souissi Sami, Orlane Anneville, Rita Adrian, Yin-Ru Chiang, Satoshi Ichise, Michio Kumagai, Shin-Ichiro S Matsuzaki, Fuh-Kwo Shiah, Jiunn-Tzong Wu, Chih-Hao Hsieh, George Sugihara, 2020, “Long-term warming destabilizes aquatic ecosystems through weakening biodiversity-mediated causal networks”, GLOBAL CHANGE BIOLOGY, 26(11), 6413-6423. (SCIE) (IF: 13.212; SCI ranking: 1.5%,2.9%,6.1%)
17. Jih-Jung Chen, Shih-Wei Wang, Yin-Ru Chiang, Ka-Lai Pang, Yueh-Hsiung Kuo, Tsai-Yen Shih, and Tzong-Huei Lee, 2020, “Highly oxygenated constituents from a marine alga-derived fungus Aspergillus giganteus NTU967”, MARINE DRUGS, 18(6), 303. (SCIE) (IF: 6.085; SCI ranking: 15.9%,17.2%)
18. Po-Hsiang Wang, Yi-Lung Chen, Sean Ting-Shyang Wei, Kan Wu, Tzong-Huei Lee, Tien-Yu Wu, and Yin-Ru Chiang*, 2020, “Retroconversion of estrogens into androgens by bacteria via a cobalamin-mediated methylation”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(3), 1395-1403. (SCIE) (IF: 12.779; SCI ranking: 12.2%)
19. Han-Yi Fu, Shao-Lun Liu, Yin-Ru Chiang*, 2020, “Biosynthesis of ascorbic acid as a glucose-induced photoprotective process in the extremophilic red alga Galdieria partita.”, Frontiers in Microbiology, 10, 3005. (SCIE) (IF: 6.064; SCI ranking: 24.6%)
20. Yin-Ru Chiang*, Sean Ting-Shyang Wei, Po-Hsiang Wang, Pei-Hsun Wu, Chang-Ping Yu, 2019, “Microbial degradation of steroid sex hormones: Implications for environmental and ecological studies.”, MICROBIAL BIOTECHNOLOGY, DOI: 10.1111/1751-7915.13504. (SCIE) (IF: 6.575; SCI ranking: 14.3%,21%)
21. Kan Wu, Tzong-Huei Lee, Yi-Lung Chen, Yu-Sheng Wang, Po-Hsiang Wang, Chang-Ping Yu, Kung-Hui Chu, and Yin-Ru Chiang*, 2019, “Metabolites Involved in Aerobic Degradation of the A and B Rings of Estrogen”, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 85(3), e02223-18. (SCIE) (IF: 5.005; SCI ranking: 28.6%,38.4%)
22. Mei-Chuan Chen, Guei-Jane Wang, Yueh-Hsiung Kuo, Yin-Ru Chiang, Ting-Yu Cho, Yu-Ming Ju, Tzong-Huei Lee*, 2019, “Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata”, JOURNAL OF FOOD AND DRUG ANALYSIS, 27(1),111-117. (SCIE) (IF: 6.157; SCI ranking: 18.8%,16.1%)
23. Sean Ting-Shyang Wei, Yu-Wei Wu, Tzong-Huei Lee, Yi-Shiang Huang, Cheng-Yu Yang, Yi-Lung Chen, and Yin-Ru Chiang*, 2018, “Microbial functional responses to cholesterol catabolism in denitrifying sludge”, mSystems, 3(5), e00113-18. (SCIE) (IF: 7.328; SCI ranking: 19.6%)
24. Min Lv, Ching Lo, Cheng-Chih Hsu, Yuwen Wang, Yin-Ru Chiang, Qian Sun, Yang Wu, Yan Li, Lingxin Chen, Chang-Ping Yu*, 2018, “Identification of enantiomeric byproducts during microalgae-mediated transformation of metoprolol by MS/MS spectrum-based networking”, FRONTIERS IN MICROBIOLOGY, 9, 2115. (SCIE) (IF: 6.064; SCI ranking: 24.6%)
25. Yi-Lung Chen, Han-Yi Fu, Tzong-Huei Lee, Chao-Jen Shih, Lina Huang, Yu-Sheng Wang, Wael Ismail, and Yin-Ru Chiang*, 2018, “Identification of estrogen degradation pathway and estrogen degraders in an activated sludge”, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 84, 84:e00001-18. (SCIE) (IF: 5.005; SCI ranking: 28.6%,38.4%)
26. Hisayoshi Nozaki1*, Noriko Ueki, Mari Takusagawa, Shota Yamashita, Osami Misumi, Ryo Matsuzaki, Masanobu Kawachi, Yin-Ru Chiang, and Jiunn-Tzong Wu, 2018, “Morphology, taxonomy and mating-type loci in natural populations of Volvox carteri in Taiwan”, BOTANICAL STUDIES, 59(1), 10. (SCIE) (IF: 2.673; SCI ranking: 40.8%)